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Many users in these forums attribute this reaction to acute mast cell activation triggered by the peptide complex, noting that they require the concurrent, daily use of potent systemic antihistamines (such as Xyzal) simply to tolerate the basic administration of the protocol

[DOI] [PubMed] [Google Scholar] 874

Current Pharmaceutical Design, 24 (26), 30623071

Fungal Genet Biol 49:302312 Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW (2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxidative species, and ageing in Saccharomyces cerevisiae